Alternative Wnt Signaling Activates YAP/TAZ
نویسندگان
چکیده
The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation independent of canonical Wnt/β-catenin signaling. Mechanistically, we delineate the "alternative Wnt-YAP/TAZ signaling axis" that consists of Wnt-FZD/ROR-Gα12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TEAD-mediated transcription. YAP/TAZ mediate the biological functions of alternative Wnt signaling, including gene expression, osteogenic differentiation, cell migration, and antagonism of Wnt/β-catenin signaling. Together, our work establishes YAP/TAZ as critical mediators of alternative Wnt signaling.
منابع مشابه
YAP/TAZ Are Effectors of Alternative WNT Signaling.
The transcriptional coactivators YAP/TAZ mediate the biologic responses of alternative WNT signaling.
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عنوان ژورنال:
- Cell
دوره 162 شماره
صفحات -
تاریخ انتشار 2015